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Our research focuses on the early stages of cognitive decline, delirium and persisting neuropsychiatric syndromes in late adulthood and old age. Our main goals are to 1) better understand the pathophysiological mechanisms associated with neurocognitive and neuropsychiatric disorders, and their relevance for the clinical manifestations and the course of disease, 2) identify and validate molecular biomarkers for prediction, early detection and differential diagnosis of cognitive impairment and related neuropsychiatric symptoms and 3) identify risk factors and protective factors of cerebral aging to assess risk and develop approaches for prevention and treatment.